UGT1A1 Genotyping Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

UGT1A1 Genotyping Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

UGT1A1 Genotyping Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

UGT1A1 Genotyping Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

UGT1A1 Genotyping Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED
UGT1A1 Genotyping Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED
  • Oncological Mutation Analysis
Product details

UGT1A1 Genotyping Kit

Real Time PCR kit for the detection of UGT1A1*28 single nucleotide polymorphism in human genomic DNA.
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- Certificate: CE-IVD.

- Description: Uridine diphosphate-glucuronyl transferase 1A1 (UGT1A1) is an enzyme that catalyzes the glucuronidation of various compounds, including steroid hormones, bilirubin, as well as xenobiotics, such as irinotecan. This process converts these substances to more water-soluble compounds that can be eliminated from the body. A polymorphic variation in the promoter of UGT1A1 leads to decreased expression of UGT1A1, resulting in reduced glucuronidation of SN-38, the active metabolite of irinotecan. Patients with a (TA)7 repeat (UGT1A1*28) have a 12-50% increased risk of Grade 4 neutropenia or severe diarrhea.3,4 Individuals that are homozygous for UGT1A1*28 mutation, that is have two alleles with 7 TA repeats (7/7 homozygous) also known as a Gilbert’s syndrome, will have the most severe toxicity to irinotecan.

- Sample material: DNA isolated from biospies, fresh/frozen tissue or whole blood

- UGT1A1*1 (wild type) is detected on FAM channel and UGT1A1*28 (mutant) is detected on HEX/VIC channel.

- Validated on: ABI Prism® -7500, StepOne, StepOne Plus, Rotor-Gene® Q

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