Ras Mutation Screening Panel - MBS BIOTECHNOLOGY COMPANY LIMITTED

Ras Mutation Screening Panel - MBS BIOTECHNOLOGY COMPANY LIMITTED

Ras Mutation Screening Panel - MBS BIOTECHNOLOGY COMPANY LIMITTED

Ras Mutation Screening Panel - MBS BIOTECHNOLOGY COMPANY LIMITTED

Ras Mutation Screening Panel - MBS BIOTECHNOLOGY COMPANY LIMITTED
Ras Mutation Screening Panel - MBS BIOTECHNOLOGY COMPANY LIMITTED
  • Oncological Mutation Analysis
Product details

Ras Mutation Screening Panel

Real Time PCR kit for detection of exon 2, 3 and 4 mutations in KRAS and NRAS in human genomic DNA isolated from tumor tissues of patients diagnosed with metastatic colorectal cancer, lung adenocarcinoma and thyroid cancer.
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​- Certificate: CE-IVD

- Description: KRAS and NRAS are members of the RAS family of GTPases that play a central role in the MAPK signaling pathway. Activating mutations in exon 2 (codon 12/13), exon 3 (codon 59/61), and exon 4 (codon 117/146) have been found in various cancers, including metastatic colorectal cancer. Recent clinical studies using anti-EGFR targeted therapies of patients diagnosed with colorectal cancer have demonstrated that tumors possessing KRAS and NRAS mutations are less likely to respond to such therapies than those without mutations.

- Sample material: DNA isolated tumor biopsies, paraffin-embedded sections (FFPE), or fresh frozen tumors.

- For KRAS screening, KRAS mutation is detected on FAM channel and IC on the HEX/VIC channel.

- For NRAS screening, NRAS mutation is detected on FAM channel and IC on the HEX/VIC channel.

- Validated on: ABI (7000, 7300, 7500/Fast, 7900HT, StepOne, StepOne Plus); Rotor-Gene (Q, 3000, 6000); LightCycler 480; Cobas® 4800,  Cobas® z480; Bio-Rad CFX96.

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