K-Ras/B-Raf Mutation Analysis Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

K-Ras/B-Raf Mutation Analysis Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

K-Ras/B-Raf Mutation Analysis Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

K-Ras/B-Raf Mutation Analysis Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

K-Ras/B-Raf Mutation Analysis Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED
K-Ras/B-Raf Mutation Analysis Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED
  • Oncological Mutation Analysis
Product details

K-Ras/B-Raf Mutation Analysis Kit

Real Time PCR kit for detection of exon 2, 3 and 4 mutations of KRAS and detection of V600E of BRAF gene in human genomic DNA isolated from tumor tissues of patients diagnosed with metastatic colorectal or lung cancers.
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- Certificate: CE-IVD

- Description: The KRAS gene encodes a small GTPase that plays a key role in transducing signals from EGFR to downstream effectors. KRAS mutations have been commonly found in several types of human malignancies, such as metastatic colorectal cancer (mCRC), lung adenocarcinoma and thyroid cancer. Mutations in BRAF, another downstream effector of the EGF-activated pathway, have been identified in up to 8% of mCRC tumors. Studies with mCRC patients have shown resistance to anti-EGFR therapy in patients with tumors expressing mutated BRAF. Both KRAS and BRAF mutations is necessary to more accurately identify tumor cells that will not respond to anti-EGFR drugs.

- Sample material: DNA isolated tumor biopsies, paraffin-embedded sections (FFPE), or fresh frozen tumors.

- For KRAS screening, KRAS mutation is detected on FAM channel and IC on the HEX/VIC channel.

- For BRAF screening, BRAF mutation is detected on FAM channel and IC on the HEX/VIC channel.

Validated: ABI (7000, 7300, 7500/Fast, 7900HT, StepOne, StepOne Plus); Rotor-Gene (Q, 3000, 6000); LightCycler 480; Cobas® 4800,  Cobas® z480; Bio-Rad CFX96

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