BCR-ABL P190 (mbcr) One-Step Detection Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

BCR-ABL P190 (mbcr) One-Step Detection Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

BCR-ABL P190 (mbcr) One-Step Detection Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

BCR-ABL P190 (mbcr) One-Step Detection Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED

BCR-ABL P190 (mbcr) One-Step Detection Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED
BCR-ABL P190 (mbcr) One-Step Detection Kit - MBS BIOTECHNOLOGY COMPANY LIMITTED
  • Oncological Mutation Analysis
Product details

BCR-ABL P190 (mbcr) One-Step Detection Kit

One-step Real Time PCR kit for quantitative detection of the BCR-ABL p190 e1a2 fusion transcript in patients who have been diagnosed with Acute Lymphoblastic Leukaemia (ALL) or Chronic Myeloid Leukemia (CML).
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- Certificate: CE-IVD

- Description: Chromosomal translocations involving BCR on chromosome 22 and ABL on chromosome 9 are the most frequent aberrations found in patients with ALL. The breakpoint on chromosome 22 occurs in the first intron of the BCR gene (minor breakpoint cluster region; mbcr), and the breakpoint on chromosome 9 occurs between exons 1 and 2 of the ABL gene (e1a2). This joins exon 1 of BCR to exon 2 of ABL, creating a 190 kDa fusion protein with a constitutively active kinase domain.

- Sample material: total RNA isolated from bone marrow or peripheral blood

- BCR-ABL fusion transcript is detected on FAM channel and ABL as Internal control on HEX/VIC channel.

- Validated on: ABI (7500, 7900HT, StepOne, StepOne Plus); Rotor-Gene (Q, 3000, 6000); LightCycler 480

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